Kars1 | lysyl-tRNA synthetase 1
Physiological systems
20 / 24 physiological systems tested
2 Significantly impacted by the knock-out
Behavior/neurological Mortality/aging
18 No significant impact
4 Not tested
Data collections
Gene metrics:3Significant phenotypes
8Associated diseases
Expression examined in:49Adult tissues
62Embryo tissues
| preweaning lethality, complete penetrance | 3 supporting datasets | Kars1tm2b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| tremors | 1 supporting dataset | Kars1tm2b(EUCOMM)Hmgu | heterozygote | Early adult | 7.18x10-5 | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Kars1tm2b(EUCOMM)Hmgu | homozygote | E9.5 | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | Wholemount images | 100% (2/2) | 0% (0/394) |
| brain | heterozygote | Wholemount images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Wholemount images | 100% (2/2) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Kars1.
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| Kars1tm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Kars1tm2b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Kars1tm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |