Erap1 | endoplasmic reticulum aminopeptidase 1
Physiological systems
18 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Adipose tissue Growth/size/body region Liver/biliary system Hematopoietic system Behavior/neurological Skeleton
11 No significant impact
6 Not tested
Data collections
Gene metrics:8Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal liver morphology | 1 supporting dataset | Erap1tm2b(EUCOMM)Wtsi | homozygote | Late adult | N/A * | ||
| decreased bone mineral content | 2 supporting datasets | Erap1tm2b(EUCOMM)Wtsi | homozygote | Early adult | 1.69x10-5 | ||
| hyperactivity | 3 supporting datasets | Erap1tm2b(EUCOMM)Wtsi | homozygote | Late adult | 1.38x10-7 | ||
| decreased total body fat amount | 1 supporting dataset | Erap1tm2b(EUCOMM)Wtsi | homozygote | Late adult | 8.43x10-5 | ||
| decreased circulating serum albumin level | 1 supporting dataset | Erap1tm2b(EUCOMM)Wtsi | homozygote | Late adult | 1.09x10-5 | ||
| increased circulating calcium level | 1 supporting dataset | Erap1tm2b(EUCOMM)Wtsi | homozygote | Late adult | 8.67x10-5 | ||
| thrombocytosis | 1 supporting dataset | Erap1tm2b(EUCOMM)Wtsi | homozygote | Early adult | 4.33x10-5 | ||
| increased lean body mass | 1 supporting dataset | Erap1tm2b(EUCOMM)Wtsi | homozygote | Late adult | 7.2x10-7 |
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Human diseases caused by Erap1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Erap1.
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| Erap1tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Erap1tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Erap1tm2a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Erap1tm2b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |