Tusc3 | tumor suppressor candidate 3
GeneMGI:1933134
Physiological systems
19 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Embryo Growth/size/body region Vision/eye Mortality/aging
15 No significant impact
5 Not tested
Data collections
Gene metrics:4Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| persistence of hyaloid vascular system | 1 supporting dataset | Tusc3em1(IMPC)J | heterozygote | Early adult | 2.19x10-5 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Tusc3em1(IMPC)J | homozygote | Early adult | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Tusc3em1(IMPC)J | homozygote | E18.5 | N/A * | ||
| abnormal body wall morphology | 1 supporting dataset | Tusc3em1(IMPC)J | homozygote | E18.5 | N/A * |
| | | | | | | | | | |
Human diseases caused by Tusc3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Tusc3.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Tusc3em1(IMPC)J | Intra-exon deletion | | mouse |
| Tusc3tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |