Tmem108 | transmembrane protein 108

GeneMGI:1932411Synonyms: B130017P16Rik

Physiological systems

19 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Hearing/vestibular/ear Vision/eye Behavior/neurological Skeleton

12 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased bone mineral content	1 supporting dataset	Tmem108^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	8.85x10^-5
increased total body fat amount	2 supporting datasets	Tmem108^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.06x10^-5
decreased lean body mass	1 supporting dataset	Tmem108^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	5.69x10^-6
abnormal cornea morphology	1 supporting dataset	Tmem108^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	6.29x10^-5
abnormal auditory brainstem response	2 supporting datasets	Tmem108^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.7x10^-5
limb grasping	1 supporting dataset	Tmem108^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	6.95x10^-5
increased circulating aspartate transaminase level	1 supporting dataset	Tmem108^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.96x10^-9

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tmem108.

Associated images

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Histopathology

There is no histopathology data found for Tmem108.

IMPC related publications

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External links

No external links available for Tmem108.

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*Tmem108^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Tmem108^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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