Tmem108 | transmembrane protein 108
Physiological systems
19 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Adipose tissue Growth/size/body region Hearing/vestibular/ear Vision/eye Behavior/neurological Skeleton
12 No significant impact
5 Not tested
Data collections
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased bone mineral content | 1 supporting dataset | Tmem108tm1b(EUCOMM)Wtsi | homozygote | Early adult | 8.85x10-5 | ||
| increased total body fat amount | 2 supporting datasets | Tmem108tm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.06x10-5 | ||
| decreased lean body mass | 1 supporting dataset | Tmem108tm1b(EUCOMM)Wtsi | homozygote | Early adult | 5.69x10-6 | ||
| abnormal cornea morphology | 1 supporting dataset | Tmem108tm1b(EUCOMM)Wtsi | homozygote | Early adult | 6.29x10-5 | ||
| abnormal auditory brainstem response | 2 supporting datasets | Tmem108tm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.7x10-5 | ||
| limb grasping | 1 supporting dataset | Tmem108tm1b(EUCOMM)Wtsi | homozygote | Early adult | 6.95x10-5 | ||
| increased circulating aspartate transaminase level | 1 supporting dataset | Tmem108tm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.96x10-9 |
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Human diseases caused by Tmem108 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Tmem108.
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| Tmem108tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Tmem108tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |