Ift122 | intraflagellar transport 122
Physiological systems
20 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Limbs/digits/tail Hematopoietic system Behavior/neurological Skeleton Mortality/aging
14 No significant impact
4 Not tested
Data collections
Viability data
Body weight measurements
Embryo imaging data
Body weight measurements
Embryo imaging data
Gene metrics:6Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| long tibia | 1 supporting dataset | Ift122tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 1.49x10-6 | ||
| decreased locomotor activity | 1 supporting dataset | Ift122tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 4.06x10-6 | ||
| increased circulating aspartate transaminase level | 1 supporting dataset | Ift122tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 2.85x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Ift122tm1a(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| increased mean corpuscular volume | 1 supporting dataset | Ift122tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 2.65x10-7 | ||
| abnormal behavior | 1 supporting dataset | Ift122tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 1.52x10-6 |
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Human diseases caused by Ift122 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ift122.
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| Ift122tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Ift122tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |