Dbr1 | debranching RNA lariats 1
GeneMGI:1931520
Physiological systems
19 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Vision/eye Mortality/aging Renal/urinary system
15 No significant impact
5 Not tested
Data collections
Gene metrics:4Significant phenotypes
2Associated diseases
Expression examined in:48Adult tissues
25Embryo tissues
| abnormal lens morphology | 1 supporting dataset | Dbr1tm1.1(KOMP)Vlcg | heterozygote | Early adult | 5.78x10-7 | ||
| decreased urine magnesium level | 1 supporting dataset | Dbr1tm1.1(KOMP)Vlcg | heterozygote | Early adult | 1.81x10-61 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Dbr1tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Dbr1tm1.1(KOMP)Vlcg | homozygote | E9.5 | N/A * |
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| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
| esophagus | heterozygote | Section images | 100% (2/2) | 1.67% (7/419) |
Human diseases caused by Dbr1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Dbr1.
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| Dbr1tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Dbr1tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Dbr1tm78661(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |