Slc35b4 | solute carrier family 35, member B4
Physiological systems
22 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Embryo Growth/size/body region Nervous system Behavior/neurological Mortality/aging Cardiovascular system
16 No significant impact
2 Not tested
Gene metrics:12Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
30Embryo tissues
| embryonic growth retardation | 1 supporting dataset | Slc35b4tm1.1(KOMP)Vlcg | homozygote | E9.5 | N/A * | ||
| hyperactivity | 3 supporting datasets | Slc35b4tm1.1(KOMP)Vlcg | heterozygote | Early adult | 3.14x10-10 | ||
| abnormal embryo size | 1 supporting dataset | Slc35b4tm1.1(KOMP)Vlcg | homozygote | E9.5 | N/A * | ||
| abnormal forebrain development | 1 supporting dataset | Slc35b4tm1.1(KOMP)Vlcg | homozygote | E9.5 | N/A * | ||
| embryonic growth retardation | 1 supporting dataset | Slc35b4tm1.1(KOMP)Vlcg | heterozygote | E9.5 | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Slc35b4tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| abnormal midbrain development | 1 supporting dataset | Slc35b4tm1.1(KOMP)Vlcg | homozygote | E9.5 | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Slc35b4tm1.1(KOMP)Vlcg | heterozygote | E9.5 | N/A * | ||
| increased heart weight | 1 supporting dataset | Slc35b4tm1.1(KOMP)Vlcg | heterozygote | Early adult | 3.61x10-6 | ||
| abnormal heart morphology | 1 supporting dataset | Slc35b4tm1.1(KOMP)Vlcg | heterozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 50% (1/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | Section images | 100% (2/2) | 7.75% (22/284) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
Human diseases caused by Slc35b4 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Slc35b4.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Slc35b4tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Slc35b4tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Slc35b4tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Slc35b4tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |