Ppp1r14a | protein phosphatase 1, regulatory inhibitor subunit 14A

GeneMGI:1931139Synonyms: Cpi17, 1110001M11Rik

Physiological systems

18 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Hearing/vestibular/ear Hematopoietic system

14 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased eosinophil cell number2 supporting datasetsPpp1r14aem1(IMPC)MarchomozygoteEarly adult9.4x10-57 
abnormal auditory brainstem response1 supporting datasetPpp1r14aem1(IMPC)MarchomozygoteEarly adult8.75x10-5 
increased basophil cell number2 supporting datasetsPpp1r14aem1(IMPC)MarchomozygoteEarly adult1.1x10-53 
increased lymphocyte cell number1 supporting datasetPpp1r14aem1(IMPC)MarchomozygoteEarly adult3.85x10-5 
increased fasting circulating glucose level1 supporting datasetPpp1r14aem1(IMPC)MarchomozygoteEarly adult4.1x10-5 
increased monocyte cell number1 supporting datasetPpp1r14aem1(IMPC)MarchomozygoteEarly adult3.23x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Ppp1r14aem1(IMPC)MarcDeletionmouse
Ppp1r14atm1(KOMP)MbpReporter-tagged deletion allele (with selection cassette)targeting vector
ES Cell
Ppp1r14atm431703(L1L2_GT0_LF2A_LacZ_BetactP_neo)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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