Pex3 | peroxisomal biogenesis factor 3
Physiological systems
20 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Adipose tissue Growth/size/body region Limbs/digits/tail Vision/eye Skeleton Cardiovascular system
13 No significant impact
4 Not tested
Data collections
Gene metrics:20Significant phenotypes
5Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| increased bone mineral density | 1 supporting dataset | Pex3tm1a(EUCOMM)Wtsi | homozygote | Early adult | 3.53x10-11 | ||
| cornea vascularization | 1 supporting dataset | Pex3tm1a(EUCOMM)Wtsi | homozygote | Early adult | 2.56x10-5 | ||
| increased bone mineral content | 1 supporting dataset | Pex3tm1a(EUCOMM)Wtsi | homozygote | Early adult | 2.1x10-5 | ||
| abnormal tail morphology | 1 supporting dataset | Pex3tm1a(EUCOMM)Wtsi | homozygote | Early adult | 3.01x10-6 | ||
| decreased body weight | 4 supporting datasets | Pex3tm1a(EUCOMM)Wtsi | homozygote | Early adult | 9.93x10-7 | ||
| increased heart weight | 1 supporting dataset | Pex3tm1a(EUCOMM)Wtsi | homozygote | Early adult | 9.39x10-6 | ||
| decreased circulating LDL cholesterol level | 1 supporting dataset | Pex3tm1a(EUCOMM)Wtsi | homozygote | Early adult | 1.97x10-7 | ||
| abnormal eye morphology | 1 supporting dataset | Pex3tm1a(EUCOMM)Wtsi | homozygote | Early adult | 2.58x10-7 | ||
| decreased total body fat amount | 1 supporting dataset | Pex3tm1a(EUCOMM)Wtsi | homozygote | Early adult | 2.17x10-10 | ||
| abnormal vertebrae morphology | 1 supporting dataset | Pex3tm1a(EUCOMM)Wtsi | homozygote | Early adult | 4.16x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/2) | 0% (0/173) |
| bone | heterozygote | n/a | 100% (2/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Pex3.
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| Pex3tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Pex3tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Pex3tm40041(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |