Amotl2 | angiomotin-like 2

GeneMGI:1929286Synonyms: MASCOT, Lccp

Physiological systems

16 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Immune system Growth/size/body region Nervous system Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system

9 No significant impact

8 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal eye morphology	2 supporting datasets	Amotl2^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
iris synechia	1 supporting dataset	Amotl2^em1(IMPC)Mbp	homozygote	Early adult	4.76x10^-10
exophthalmos	1 supporting dataset	Amotl2^em1(IMPC)Mbp	homozygote	Early adult	3.06x10^-15
decreased prepulse inhibition	2 supporting datasets	Amotl2^em1(IMPC)Mbp	homozygote	Early adult	3.37x10^-5
increased heart weight	2 supporting datasets	Amotl2^em1(IMPC)Mbp	homozygote	Early adult	4.16x10^-5
abnormal cornea morphology	1 supporting dataset	Amotl2^em1(IMPC)Mbp	homozygote	Early adult	1.3x10^-7
decreased body length	1 supporting dataset	Amotl2^em1(IMPC)Mbp	homozygote	Early adult	2.21x10^-8
impaired pupillary reflex	1 supporting dataset	Amotl2^em1(IMPC)Mbp	homozygote	Early adult	1x10^-14
cornea opacity	1 supporting dataset	Amotl2^em1(IMPC)Mbp	homozygote	Early adult	1.55x10^-12
abnormal lens morphology	1 supporting dataset	Amotl2^em1(IMPC)Mbp	homozygote	Early adult	8.49x10^-12

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Amotl2.

Associated images

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Histopathology

There is no histopathology data found for Amotl2.

IMPC related publications

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External links

No external links available for Amotl2.

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*Amotl2^em1(IMPC)Mbp*	Inter-exon deletion	‌	mouse
*Amotl2^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector es cell
*Amotl2^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Amotl2^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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