Amotl2 | angiomotin-like 2

GeneMGI:1929286Synonyms: MASCOT, Lccp

Physiological systems

16 / 24 physiological systems tested

7 Significantly impacted by the knock-out

 Immune system Growth/size/body region Nervous system Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system

9 No significant impact

8 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:12Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal eye morphology2 supporting datasetsAmotl2em1(IMPC)MbphomozygoteEarly adultN/A * 
iris synechia1 supporting datasetAmotl2em1(IMPC)MbphomozygoteEarly adult4.76x10-10 
exophthalmos1 supporting datasetAmotl2em1(IMPC)MbphomozygoteEarly adult3.06x10-15 
decreased prepulse inhibition2 supporting datasetsAmotl2em1(IMPC)MbphomozygoteEarly adult3.37x10-5 
increased heart weight2 supporting datasetsAmotl2em1(IMPC)MbphomozygoteEarly adult4.16x10-5 
abnormal cornea morphology1 supporting datasetAmotl2em1(IMPC)MbphomozygoteEarly adult1.3x10-7 
decreased body length1 supporting datasetAmotl2em1(IMPC)MbphomozygoteEarly adult2.21x10-8 
impaired pupillary reflex1 supporting datasetAmotl2em1(IMPC)MbphomozygoteEarly adult1x10-14 
cornea opacity1 supporting datasetAmotl2em1(IMPC)MbphomozygoteEarly adult1.55x10-12 
abnormal lens morphology1 supporting datasetAmotl2em1(IMPC)MbphomozygoteEarly adult8.49x10-12 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Amotl2em1(IMPC)MbpInter-exon deletionmouse
Amotl2tm1(NCOM)MfgcReporter-tagged deletion allele (with selection cassette)targeting vector
ES Cell
Amotl2tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Amotl2tm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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