Pfdn5 | prefoldin 5
Physiological systems
21 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Homeostasis/metabolism Integument Adipose tissue Embryo Growth/size/body region Limbs/digits/tail Mortality/aging Craniofacial
13 No significant impact
3 Not tested
Gene metrics:10Significant phenotypes
0Associated diseases
Expression examined in:50Adult tissues
62Embryo tissues
| abnormal craniofacial morphology | 1 supporting dataset | Pfdn5tm1b(EUCOMM)Wtsi | homozygote | E15.5 | N/A * | ||
| decreased lean body mass | 1 supporting dataset | Pfdn5tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 4.92x10-5 | ||
| increased total body fat amount | 2 supporting datasets | Pfdn5tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.88x10-5 | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Pfdn5tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| prenatal lethality | 1 supporting dataset | Pfdn5tm1b(EUCOMM)Wtsi | homozygote | E18.5 | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Pfdn5tm1b(EUCOMM)Wtsi | homozygote | E12.5 | N/A * | ||
| edema | 1 supporting dataset | Pfdn5tm1b(EUCOMM)Wtsi | homozygote | E15.5 | N/A * | ||
| abnormal skin coloration | 1 supporting dataset | Pfdn5tm1b(EUCOMM)Wtsi | homozygote | E15.5 | N/A * | ||
| abnormal tail morphology | 1 supporting dataset | Pfdn5tm1b(EUCOMM)Wtsi | homozygote | E15.5 | N/A * | ||
| embryonic growth retardation | 1 supporting dataset | Pfdn5tm1b(EUCOMM)Wtsi | homozygote | E15.5 | N/A * |
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| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | Wholemount images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Wholemount images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Wholemount images | 100% (1/1) | 0.22% (1/454) |
| cerebellum | heterozygote | Wholemount images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Wholemount images | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Pfdn5 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Pfdn5.
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| Pfdn5tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Pfdn5tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Pfdn5tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |