Keg1 | kidney expressed gene 1
Physiological systems
17 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Hematopoietic system Behavior/neurological
14 No significant impact
7 Not tested
Data collections
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:48Adult tissues
50Embryo tissues
| increased erythrocyte cell number | 1 supporting dataset | Keg1tm1b(KOMP)Mbp | homozygote | Early adult | 4.89x10-5 | ||
| hyperactivity | 6 supporting datasets | Keg1tm1b(KOMP)Mbp | homozygote | Early adult | 2.73x10-5 | ||
| decreased thigmotaxis | 2 supporting datasets | Keg1tm1b(KOMP)Mbp | homozygote | Early adult | 6.1x10-6 | ||
| increased circulating calcium level | 1 supporting dataset | Keg1tm1b(KOMP)Mbp | homozygote | Early adult | 6.85x10-5 | ||
| increased hemoglobin content | 1 supporting dataset | Keg1tm1b(KOMP)Mbp | homozygote | Early adult | 2.1x10-5 | ||
| increased circulating bilirubin level | 1 supporting dataset | Keg1tm1b(KOMP)Mbp | homozygote | Early adult | 5.24x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| epididymis | heterozygote | n/a | 0% (0/1) | 87.5% (21/24) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Keg1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Keg1.
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| Keg1tm1a(KOMP)Mbp | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Keg1tm1b(KOMP)Mbp | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Keg1tm1e(KOMP)Mbp | Targeted, non-conditional allele | | ES Cell |