Tdo2 | tryptophan 2,3-dioxygenase
Physiological systems
19 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Embryo Growth/size/body region Nervous system Vision/eye Mortality/aging Cardiovascular system
12 No significant impact
5 Not tested
Gene metrics:8Significant phenotypes
2Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
| edema | 1 supporting dataset | Tdo2tm1b(KOMP)Mbp | homozygote | E15.5 | N/A * | ||
| preweaning lethality, incomplete penetrance | 2 supporting datasets | Tdo2tm1b(KOMP)Mbp | homozygote | Early adult | N/A * | ||
| increased heart weight | 2 supporting datasets | Tdo2tm1b(KOMP)Mbp | heterozygote | Early adult | 2x10-5 | ||
| increased prepulse inhibition | 1 supporting dataset | Tdo2tm1b(KOMP)Mbp | heterozygote | Early adult | 1.78x10-6 | ||
| microphthalmia | 1 supporting dataset | Tdo2tm1b(KOMP)Mbp | homozygote | E15.5 | N/A * | ||
| enlarged heart | 1 supporting dataset | Tdo2tm1b(KOMP)Mbp | heterozygote | Early adult | N/A * | ||
| abnormal heart morphology | 1 supporting dataset | Tdo2tm1b(KOMP)Mbp | heterozygote | Early adult | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Tdo2tm1b(KOMP)Mbp | homozygote | E15.5 | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
Human diseases caused by Tdo2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Tdo2.
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| Tdo2tm1a(KOMP)Mbp | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Tdo2tm1b(KOMP)Mbp | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Tdo2tm1e(KOMP)Mbp | Targeted, non-conditional allele | | ES Cell |
| Tdo2tm2a(KOMP)Mbp | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Tdo2tm2e(KOMP)Mbp | Targeted, non-conditional allele | | ES Cell |
| Tdo2tm41820(L1L2_gt0) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |