Dnaja4 | DnaJ heat shock protein family (Hsp40) member A4
Physiological systems
18 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Hematopoietic system Behavior/neurological
15 No significant impact
6 Not tested
Data collections
Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:49Adult tissues
50Embryo tissues
| decreased circulating glucose level | 1 supporting dataset | Dnaja4tm1b(KOMP)Wtsi | homozygote | Early adult | 1.12x10-5 | ||
| increased mean corpuscular hemoglobin concentration | 1 supporting dataset | Dnaja4tm1b(KOMP)Wtsi | homozygote | Early adult | 9.59x10-6 | ||
| decreased mean corpuscular volume | 1 supporting dataset | Dnaja4tm1b(KOMP)Wtsi | homozygote | Early adult | 3.44x10-6 | ||
| abnormal sleep behavior | 1 supporting dataset | Dnaja4tm1b(KOMP)Wtsi | homozygote | Early adult | 5.48x10-5 |
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| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
Human diseases caused by Dnaja4 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Dnaja4.
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| Dnaja4tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Dnaja4tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Dnaja4tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Dnaja4tm2a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Dnaja4tm2e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |