Afg2a | AFG2 AAA ATPase homolog A
Physiological systems
18 / 24 physiological systems tested
2 Significantly impacted by the knock-out
Integument Mortality/aging
16 No significant impact
6 Not tested
Data collections
Gene metrics:3Significant phenotypes
2Associated diseases
Expression examined in:51Adult tissues
62Embryo tissues
| embryonic lethality prior to organogenesis | 1 supporting dataset | Afg2atm1b(KOMP)Wtsi | homozygote | E9.5 | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Afg2atm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal skin coloration | 1 supporting dataset | Afg2atm1b(KOMP)Wtsi | heterozygote | Early adult | 3.68x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | Wholemount images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | Wholemount images | 100% (2/2) | 0% (0/394) |
| brain | heterozygote | Wholemount images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Wholemount images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Wholemount images | 100% (2/2) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
| cerebellum | heterozygote | Wholemount images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Wholemount images | 100% (2/2) | 0.41% (2/491) |
Human diseases caused by Afg2a mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Afg2a.
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| Afg2atm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Afg2atm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Afg2atm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Afg2atm297767(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Afg2atm35769(pL1L2_GT0_DelLacZ_bsd) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |