Ppp1r15a | protein phosphatase 1, regulatory subunit 15A
Physiological systems
14 / 24 physiological systems tested
2 Significantly impacted by the knock-out
Homeostasis/metabolism Hematopoietic system
12 No significant impact
10 Not tested
Data collections
Gene metrics:3Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased red blood cell distribution width | 1 supporting dataset | Ppp1r15aem2(IMPC)H | homozygote | Early adult | 2.16x10-16 | ||
| decreased mean corpuscular hemoglobin | 1 supporting dataset | Ppp1r15aem2(IMPC)H | homozygote | Early adult | 1.93x10-7 | ||
| increased circulating alanine transaminase level | 1 supporting dataset | Ppp1r15aem2(IMPC)H | homozygote | Early adult | 3.19x10-5 |
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Human diseases caused by Ppp1r15a mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ppp1r15a.
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| Ppp1r15aem1(IMPC)H | Indel | | mouse |
| Ppp1r15aem2(IMPC)H | Indel | | mouse |
| Ppp1r15atm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Ppp1r15atm221653(L1L2_Bact_P) | Reporter-tagged deletion allele (with selection cassette) | | targeting vector |