Postn | periostin, osteoblast specific factor
Physiological systems
17 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Hematopoietic system Behavior/neurological Skeleton
12 No significant impact
7 Not tested
Data collections
Gene metrics:11Significant phenotypes
0Associated diseases
Expression examined in:48Adult tissues
50Embryo tissues
| abnormal bone structure | 1 supporting dataset | Postntm1.1(KOMP)Vlcg | homozygote | Early adult | 1.93x10-8 | ||
| decreased body length | 1 supporting dataset | Postntm1.1(KOMP)Vlcg | homozygote | Early adult | 6.28x10-21 | ||
| decreased bone mineral content | 1 supporting dataset | Postntm1.1(KOMP)Vlcg | homozygote | Early adult | 1.41x10-5 | ||
| decreased bone mineral density | 1 supporting dataset | Postntm1.1(KOMP)Vlcg | homozygote | Early adult | 1.65x10-6 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Postntm1.1(KOMP)Vlcg | homozygote | Early adult | 9.32x10-10 | ||
| increased grip strength | 2 supporting datasets | Postntm1.1(KOMP)Vlcg | homozygote | Early adult | 5.52x10-17 | ||
| thrombocytosis | 1 supporting dataset | Postntm1.1(KOMP)Vlcg | homozygote | Early adult | 3.77x10-7 | ||
| abnormal sleep behavior | 3 supporting datasets | Postntm1.1(KOMP)Vlcg | homozygote | Early adult | 7.38x10-10 | ||
| increased bone mineral content | 1 supporting dataset | Postntm1.1(KOMP)Vlcg | homozygote | Early adult | 4.55x10-6 | ||
| decreased thigmotaxis | 2 supporting datasets | Postntm1.1(KOMP)Vlcg | homozygote | Early adult | 8.38x10-6 |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
| esophagus | heterozygote | Section images | 100% (2/2) | 1.67% (7/419) |
Human diseases caused by Postn mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Postn.
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| Postntm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Postntm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Postntm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |