Tnip1 | TNFAIP3 interacting protein 1
Physiological systems
16 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Growth/size/body region Hematopoietic system Behavior/neurological
11 No significant impact
8 Not tested
Data collections
Gene metrics:25Significant phenotypes
1Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
| decreased circulating serum albumin level | 1 supporting dataset | Tnip1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.13x10-11 | ||
| decreased lymphocyte cell number | 1 supporting dataset | Tnip1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 8.43x10-8 | ||
| increased red blood cell distribution width | 1 supporting dataset | Tnip1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.27x10-35 | ||
| decreased erythrocyte cell number | 1 supporting dataset | Tnip1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 6.08x10-30 | ||
| increased basophil cell number | 1 supporting dataset | Tnip1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 6.81x10-7 | ||
| increased circulating alanine transaminase level | 1 supporting dataset | Tnip1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.32x10-88 | ||
| increased large unstained cell number | 2 supporting datasets | Tnip1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.3x10-18 | ||
| increased freezing behavior | 2 supporting datasets | Tnip1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.68x10-6 | ||
| increased circulating aspartate transaminase level | 1 supporting dataset | Tnip1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 9.75x10-31 | ||
| increased mean platelet volume | 1 supporting dataset | Tnip1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.9x10-49 |
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| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Tnip1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Tnip1.
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| Tnip1tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Tnip1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Tnip1tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Tnip1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Tnip1tm33632(L1L2_gt1) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |