Ltn1 | listerin E3 ubiquitin protein ligase 1
Physiological systems
23 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Growth/size/body region Vision/eye Respiratory system Hematopoietic system Behavior/neurological Mortality/aging
15 No significant impact
1 Not tested
Gene metrics:12Significant phenotypes
0Associated diseases
Expression examined in:78Adult tissues
63Embryo tissues
| decreased circulating alkaline phosphatase level | 1 supporting dataset | Ltn1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.23x10-10 | ||
| no spontaneous movement | 1 supporting dataset | Ltn1tm1b(EUCOMM)Hmgu | homozygote | E18.5 | N/A * | ||
| increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number | 1 supporting dataset | Ltn1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 8.59x10-5 | ||
| increased lung elastance | 3 supporting datasets | Ltn1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.47x10-6 | ||
| increased freezing behavior | 1 supporting dataset | Ltn1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.59x10-5 | ||
| increased red blood cell distribution width | 1 supporting dataset | Ltn1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 7.8x10-6 | ||
| increased lung tissue damping | 2 supporting datasets | Ltn1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 5.29x10-6 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Ltn1tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| increased airway resistance | 1 supporting dataset | Ltn1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 3.65x10-5 | ||
| thrombocytopenia | 1 supporting dataset | Ltn1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.53x10-12 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 50% (1/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 100% (2/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | n/a | 0% (0/17) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| bone marrow | heterozygote | n/a | n/a | 0% (0/22) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 100% (2/2) | 7.75% (22/284) |
Human diseases caused by Ltn1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ltn1.
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| Ltn1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Ltn1tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Ltn1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |