Fhod3 | formin homology 2 domain containing 3
Physiological systems
22 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Embryo Growth/size/body region Nervous system Vision/eye Behavior/neurological Mortality/aging Cardiovascular system
15 No significant impact
2 Not tested
Data collections
Gene metrics:14Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal neural tube morphology | 1 supporting dataset | Fhod3em1(IMPC)Mbp | heterozygote | E9.5 | N/A * | ||
| decreased exploration in new environment | 1 supporting dataset | Fhod3em1(IMPC)Mbp | heterozygote | Early adult | 8.9x10-5 | ||
| abnormal neural tube closure | 1 supporting dataset | Fhod3em1(IMPC)Mbp | homozygote | E9.5 | N/A * | ||
| embryonic growth retardation | 1 supporting dataset | Fhod3em1(IMPC)Mbp | homozygote | E9.5 | N/A * | ||
| abnormal neural tube morphology | 1 supporting dataset | Fhod3em1(IMPC)Mbp | homozygote | E9.5 | N/A * | ||
| abnormal neural tube closure | 1 supporting dataset | Fhod3em1(IMPC)Mbp | heterozygote | E9.5 | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Fhod3em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| increased freezing behavior | 1 supporting dataset | Fhod3em1(IMPC)Mbp | heterozygote | Early adult | 4.44x10-5 | ||
| abnormal placenta vasculature | 1 supporting dataset | Fhod3em1(IMPC)Mbp | heterozygote | E15.5 | N/A * | ||
| abnormal forebrain development | 1 supporting dataset | Fhod3em1(IMPC)Mbp | homozygote | E9.5 | N/A * |
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Human diseases caused by Fhod3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Fhod3.
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| Fhod3em1(IMPC)Mbp | Exon Deletion | | mouse |