Atrip | ATR interacting protein
Physiological systems
19 / 24 physiological systems tested
2 Significantly impacted by the knock-out
Homeostasis/metabolism Mortality/aging
17 No significant impact
5 Not tested
Data collections
Gene metrics:5Significant phenotypes
1Associated diseases
Expression examined in:48Adult tissues
25Embryo tissues
decreased fasting circulating glucose level | 1 supporting dataset | Atriptm1b(KOMP)Wtsi | heterozygote | Early adult | 2.18x10-10 | ||
increased circulating sodium level | 1 supporting dataset | Atriptm1b(KOMP)Wtsi | heterozygote | Early adult | 3.25x10-8 | ||
embryonic lethality prior to organogenesis | 1 supporting dataset | Atriptm1b(KOMP)Wtsi | homozygote | E9.5 | N/A * | ||
preweaning lethality, complete penetrance | 1 supporting dataset | Atriptm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
increased circulating chloride level | 1 supporting dataset | Atriptm1b(KOMP)Wtsi | heterozygote | Early adult | 5.37x10-5 |
| | | | | | | | | |
adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
cartilage tissue | heterozygote | Section images | 100% (2/2) | 0.22% (1/454) |
cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
esophagus | heterozygote | Section images | 100% (2/2) | 1.67% (7/419) |
Human diseases caused by Atrip mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Atrip.
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Atriptm119157(L1L2_Pgk_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
Atriptm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
Atriptm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
Atriptm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |