Limch1 | LIM and calponin homology domains 1
Physiological systems
18 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Vision/eye Behavior/neurological Mortality/aging
15 No significant impact
6 Not tested
Data collections
Gene metrics:3Significant phenotypes
0Associated diseases
Expression examined in:48Adult tissues
50Embryo tissues
| abnormal retina morphology | 1 supporting dataset | Limch1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 4.19x10-7 | ||
| abnormal sleep behavior | 1 supporting dataset | Limch1tm1b(EUCOMM)Hmgu | homozygote | Early adult | 3.37x10-5 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Limch1tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/1) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
| epididymis | heterozygote | n/a | 0% (0/1) | 87.5% (21/24) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Limch1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Limch1.
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| Limch1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Limch1tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Limch1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Limch1tm46051(L1L2_gt1) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |