Agl | amylo-1,6-glucosidase, 4-alpha-glucanotransferase
Physiological systems
20 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Homeostasis/metabolism Adipose tissue Growth/size/body region Vision/eye Behavior/neurological Skeleton Cardiovascular system Mortality/aging Renal/urinary system
11 No significant impact
4 Not tested
Data collections
Gene metrics:21Significant phenotypes
2Associated diseases
Expression examined in:46Adult tissues
0Embryo tissues
| increased heart weight | 1 supporting dataset | Agltm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.75x10-10 | ||
| cataract | 1 supporting dataset | Agltm1b(EUCOMM)Wtsi | homozygote | Early adult | 3.7x10-14 | ||
| increased circulating cholesterol level | 1 supporting dataset | Agltm1b(EUCOMM)Wtsi | homozygote | Early adult | 6.1x10-5 | ||
| increased kidney weight | 1 supporting dataset | Agltm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.94x10-9 | ||
| increased lean body mass | 1 supporting dataset | Agltm1b(EUCOMM)Wtsi | homozygote | Early adult | 8.49x10-9 | ||
| decreased bone mineral content | 2 supporting datasets | Agltm1b(EUCOMM)Wtsi | homozygote | Early adult | 7.12x10-9 | ||
| increased circulating iron level | 1 supporting dataset | Agltm1b(EUCOMM)Wtsi | homozygote | Early adult | 0 | ||
| decreased circulating glucose level | 1 supporting dataset | Agltm1b(EUCOMM)Wtsi | homozygote | Early adult | 0 | ||
| abnormal gait | 1 supporting dataset | Agltm1b(EUCOMM)Wtsi | homozygote | Early adult | 7.75x10-5 | ||
| tremors | 1 supporting dataset | Agltm1b(EUCOMM)Wtsi | heterozygote | Early adult | 2.97x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/4) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/4) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/4) | 0% (0/394) |
| brain | heterozygote | n/a | 0% (0/4) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/4) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/4) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/4) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/4) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/4) | 1.67% (7/419) |
Human diseases caused by Agl mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Agl.
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| Agltm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Agltm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Agltm1c(EUCOMM)Wtsi | Wild type floxed exon (post-Flp) | | mouse |
| Agltm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |