Tmem116 | transmembrane protein 116
Physiological systems
21 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Growth/size/body region Vision/eye Respiratory system Hematopoietic system Behavior/neurological
14 No significant impact
3 Not tested
Data collections
Gene metrics:10Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal lens morphology | 2 supporting datasets | Tmem116tm1b(EUCOMM)Hmgu | homozygote | Early adult | 4.21x10-9 | ||
| enlarged lymph nodes | 1 supporting dataset | Tmem116tm1b(EUCOMM)Hmgu | homozygote | Late adult | N/A * | ||
| abnormal lung morphology | 1 supporting dataset | Tmem116tm1b(EUCOMM)Hmgu | homozygote | Late adult | N/A * | ||
| decreased body weight | 1 supporting dataset | Tmem116tm1b(EUCOMM)Hmgu | homozygote | Middle aged adult | 5.78x10-5 | ||
| improved glucose tolerance | 1 supporting dataset | Tmem116tm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.1x10-6 | ||
| enlarged spleen | 1 supporting dataset | Tmem116tm1b(EUCOMM)Hmgu | homozygote | Late adult | N/A * | ||
| decreased circulating alkaline phosphatase level | 1 supporting dataset | Tmem116tm1b(EUCOMM)Hmgu | homozygote | Early adult | 6.74x10-5 | ||
| increased grip strength | 1 supporting dataset | Tmem116tm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.11x10-5 | ||
| abnormal startle reflex | 1 supporting dataset | Tmem116tm1b(EUCOMM)Hmgu | homozygote | Late adult | 1.58x10-6 | ||
| decreased circulating total protein level | 1 supporting dataset | Tmem116tm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.85x10-6 |
| | | | | | | | | | |
Human diseases caused by Tmem116 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Tmem116.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Tmem116tm1(NCOM)Cmhd | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Tmem116tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Tmem116tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Tmem116tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |