Coq6 | coenzyme Q6 monooxygenase

GeneMGI:1924408Synonyms: 5930427M12Rik

Physiological systems

22 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Embryo Growth/size/body region Limbs/digits/tail Nervous system Vision/eye Mortality/aging

15 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

3Associated diseases

Expression examined in:48Adult tissues

25Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



embryonic growth retardation	1 supporting dataset	Coq6^{tm1b(EUCOMM)Hmgu}	homozygote	E9.5	N/A ^*
persistence of hyaloid vascular system	1 supporting dataset	Coq6^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.59x10^-6
abnormal tail bud morphology	1 supporting dataset	Coq6^{tm1b(EUCOMM)Hmgu}	homozygote	E9.5	N/A ^*
preweaning lethality, complete penetrance	2 supporting datasets	Coq6^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
abnormal forebrain development	1 supporting dataset	Coq6^{tm1b(EUCOMM)Hmgu}	homozygote	E9.5	N/A ^*
embryonic lethality prior to tooth bud stage	1 supporting dataset	Coq6^{tm1b(EUCOMM)Hmgu}	homozygote	E12.5	N/A ^*
abnormal cornea morphology	1 supporting dataset	Coq6^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.91x10^-5
increased fasting circulating glucose level	1 supporting dataset	Coq6^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	3.56x10^-7
increased circulating sodium level	1 supporting dataset	Coq6^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.68x10^-9
abnormal embryo size	1 supporting dataset	Coq6^{tm1b(EUCOMM)Hmgu}	homozygote	E9.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Coq6.

Associated images

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Histopathology

There is no histopathology data found for Coq6.

IMPC related publications

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External links

No external links available for Coq6.

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*Coq6^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Coq6^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Coq6^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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