Pacs2 | phosphofurin acidic cluster sorting protein 2
Physiological systems
20 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Adipose tissue Limbs/digits/tail Nervous system Hematopoietic system Behavior/neurological Skeleton
13 No significant impact
4 Not tested
Data collections
Viability data
Body weight measurements
Embryo imaging data
Body weight measurements
Embryo imaging data
Gene metrics:7Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased hemoglobin content | 1 supporting dataset | Pacs2tm1a(EUCOMM)Hmgu | homozygote | Early adult | 1.46x10-5 | ||
| increased startle reflex | 5 supporting datasets | Pacs2tm1a(EUCOMM)Hmgu | homozygote | Early adult | 2.96x10-28 | ||
| decreased prepulse inhibition | 2 supporting datasets | Pacs2tm1a(EUCOMM)Hmgu | homozygote | Early adult | 2.02x10-5 | ||
| short tibia | 1 supporting dataset | Pacs2tm1a(EUCOMM)Hmgu | homozygote | Early adult | 1.76x10-5 | ||
| abnormal behavior | 3 supporting datasets | Pacs2tm1a(EUCOMM)Hmgu | homozygote | Early adult | 2.63x10-7 | ||
| increased total body fat amount | 1 supporting dataset | Pacs2tm1a(EUCOMM)Hmgu | homozygote | Early adult | 2.72x10-5 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Pacs2tm1a(EUCOMM)Hmgu | homozygote | Early adult | 3.21x10-5 |
| | | | | | | | | | |
Human diseases caused by Pacs2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Pacs2.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Pacs2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Pacs2tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Pacs2tm80423(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |