Kdm8 | lysine (K)-specific demethylase 8
Physiological systems
22 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Homeostasis/metabolism Pigmentation Immune system Integument Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Mortality/aging
13 No significant impact
2 Not tested
Gene metrics:10Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
21Embryo tissues
| increased body weight | 1 supporting dataset | Kdm8tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 1.57x10-5 | ||
| abnormal behavior | 3 supporting datasets | Kdm8tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 5.48x10-7 | ||
| increased IgE level | 1 supporting dataset | Kdm8tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 7.1x10-6 | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Kdm8tm1b(EUCOMM)Wtsi | homozygote | E12.5 | N/A * | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Kdm8tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal response to tactile stimuli | 1 supporting dataset | Kdm8tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 3.53x10-7 | ||
| abnormal iris pigmentation | 1 supporting dataset | Kdm8tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 2.79x10-5 | ||
| abnormal behavior | 1 supporting dataset | Kdm8tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.2x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Kdm8tm1a(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| increased circulating potassium level | 1 supporting dataset | Kdm8tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 2.77x10-7 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/4) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/4) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/4) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (4/4) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (4/4) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/4) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (4/4) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 100% (4/4) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (4/4) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/4) | 1.67% (7/419) |
Human diseases caused by Kdm8 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Kdm8.
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| Kdm8tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Kdm8tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Kdm8tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |