Kdm8 | lysine (K)-specific demethylase 8

GeneMGI:1924285Synonyms: Jmjd5, 3110005O21Rik

Physiological systems

22 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Pigmentation Immune system Integument Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Mortality/aging

13 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:46Adult tissues

21Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:

Life Stage:



increased body weight	1 supporting dataset	Kdm8^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	1.57x10^-5
abnormal behavior	3 supporting datasets	Kdm8^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	5.48x10^-7
increased IgE level	1 supporting dataset	Kdm8^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	7.1x10^-6
embryonic lethality prior to tooth bud stage	1 supporting dataset	Kdm8^{tm1b(EUCOMM)Wtsi}	homozygote	E12.5	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Kdm8^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
abnormal response to tactile stimuli	1 supporting dataset	Kdm8^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	3.53x10^-7
abnormal iris pigmentation	1 supporting dataset	Kdm8^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	2.79x10^-5
abnormal behavior	1 supporting dataset	Kdm8^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.2x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Kdm8^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased circulating potassium level	1 supporting dataset	Kdm8^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	2.77x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Kdm8.

Associated images

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Histopathology

There is no histopathology data found for Kdm8.

IMPC related publications

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External links

No external links available for Kdm8.

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*Kdm8^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Kdm8^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Kdm8^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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