Nubpl | nucleotide binding protein-like
Physiological systems
18 / 24 physiological systems tested
1 Significantly impacted by the knock-out
Mortality/aging
17 No significant impact
6 Not tested
Data collections
Gene metrics:2Significant phenotypes
2Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| prenatal lethality prior to heart atrial septation | 1 supporting dataset | Nubpltm1b(KOMP)Wtsi | homozygote | E15.5 | N/A * | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Nubpltm1b(KOMP)Wtsi | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/2) | 0% (0/173) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
Human diseases caused by Nubpl mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Nubpl.
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| Nubpltm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Nubpltm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Nubpltm1c(KOMP)Wtsi | Wild type floxed exon (post-Flp) | | mouse |
| Nubpltm82891(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |