Elapor1 | endosome-lysosome associated apoptosis and autophagy regulator 1
Physiological systems
19 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Limbs/digits/tail Vision/eye Hematopoietic system Behavior/neurological Skeleton Cardiovascular system Mortality/aging
10 No significant impact
5 Not tested
Data collections
Gene metrics:9Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal retina vasculature morphology | 1 supporting dataset | Elapor1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 5.57x10-6 | ||
| abnormal retina blood vessel morphology | 1 supporting dataset | Elapor1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 4.44x10-6 | ||
| increased circulating glucose level | 1 supporting dataset | Elapor1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 4.78x10-5 | ||
| increased fluid intake | 1 supporting dataset | Elapor1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 2.12x10-5 | ||
| short tibia | 2 supporting datasets | Elapor1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 2.68x10-7 | ||
| abnormal vitreous body morphology | 1 supporting dataset | Elapor1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 7.03x10-6 | ||
| decreased exploration in new environment | 1 supporting dataset | Elapor1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 2.28x10-10 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Elapor1tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| decreased lymphocyte cell number | 1 supporting dataset | Elapor1tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 7.96x10-5 |
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Human diseases caused by Elapor1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Elapor1.
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| Elapor1tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Elapor1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Elapor1tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Elapor1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Elapor1tm401(L1L2_gt0) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |