Wipi2 | WD repeat domain, phosphoinositide interacting 2
Physiological systems
16 / 24 physiological systems tested
2 Significantly impacted by the knock-out
Vision/eye Mortality/aging
14 No significant impact
8 Not tested
Data collections
Gene metrics:2Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| preweaning lethality, complete penetrance | 2 supporting datasets | Wipi2em1(IMPC)Bay | homozygote | Early adult | N/A * | ||
| increased total retina thickness | 1 supporting dataset | Wipi2em1(IMPC)Bay | heterozygote | Early adult | 2.76x10-5 |
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Human diseases caused by Wipi2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Wipi2.
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| Wipi2em1(IMPC)Bay | Exon Deletion | | mouse |
| Wipi2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Wipi2tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |