Cog2 | component of oligomeric golgi complex 2
Physiological systems
20 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Mortality/aging
17 No significant impact
4 Not tested
Data collections
Gene metrics:4Significant phenotypes
2Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| decreased circulating aspartate transaminase level | 1 supporting dataset | Cog2tm1a(KOMP)Wtsi | heterozygote | Early adult | 1.04x10-7 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Cog2tm1a(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| increased circulating free fatty acids level | 1 supporting dataset | Cog2tm1a(KOMP)Wtsi | heterozygote | Early adult | 9.85x10-5 | ||
| decreased body weight | 2 supporting datasets | Cog2tm1a(KOMP)Wtsi | heterozygote | Early adult | 6.47x10-6 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/2) | 0% (0/173) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
Human diseases caused by Cog2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Cog2.
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| Cog2tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Cog2tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Cog2tm2a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Cog2tm3a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Cog2tm42369(L1L2_Pgk_PM) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |