Fam227b | family with sequence similarity 227, member B
Physiological systems
23 / 24 physiological systems tested
12 Significantly impacted by the knock-out
Reproductive system Immune system Endocrine/exocrine gland Integument Growth/size/body region Digestive/alimentary Muscle Hematopoietic system Behavior/neurological Skeleton Craniofacial Cardiovascular system
11 No significant impact
1 Not tested
Data collections
Gene metrics:21Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal duodenum morphology | 1 supporting dataset | Fam227bem1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| enlarged heart | 1 supporting dataset | Fam227bem1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| abnormal epididymis morphology | 1 supporting dataset | Fam227bem1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| abnormal thymus morphology | 1 supporting dataset | Fam227bem1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| male infertility | 1 supporting dataset | Fam227bem1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| abnormal lymph node morphology | 1 supporting dataset | Fam227bem1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| enlarged thymus | 1 supporting dataset | Fam227bem1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| abnormal tooth morphology | 1 supporting dataset | Fam227bem1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| enlarged epididymis | 1 supporting dataset | Fam227bem1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| abnormal jejunum morphology | 1 supporting dataset | Fam227bem1(IMPC)Ccpcz | homozygote | Early adult | N/A * |
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Human diseases caused by Fam227b mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Fam227b.
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| Fam227bem1(IMPC)Ccpcz | Exon Deletion | | mouse |
| Fam227btm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Fam227btm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Fam227btm39433(L1L2_gt0) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |