Ckap5 | cytoskeleton associated protein 5
Physiological systems
20 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Embryo Growth/size/body region Vision/eye Mortality/aging
15 No significant impact
4 Not tested
Data collections
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:51Adult tissues
62Embryo tissues
| abnormal retina outer nuclear layer morphology | 2 supporting datasets | Ckap5tm2b(EUCOMM)Hmgu | heterozygote | Early adult | 1.91x10-11 | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Ckap5tm2b(EUCOMM)Hmgu | homozygote | E9.5 | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Ckap5tm2b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| abnormal embryo turning | 1 supporting dataset | Ckap5tm2b(EUCOMM)Hmgu | heterozygote | E9.5 | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Ckap5tm2b(EUCOMM)Hmgu | heterozygote | E9.5 | N/A * | ||
| decreased body temperature | 1 supporting dataset | Ckap5tm2b(EUCOMM)Hmgu | heterozygote | Early adult | 1.71x10-6 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
Human diseases caused by Ckap5 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ckap5.
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| Ckap5tm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Ckap5tm2b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Ckap5tm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |