Fastkd2 | FAST kinase domains 2
Physiological systems
18 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Immune system Integument Vision/eye Hematopoietic system Mortality/aging
13 No significant impact
6 Not tested
Data collections
Gene metrics:4Significant phenotypes
2Associated diseases
Expression examined in:51Adult tissues
0Embryo tissues
| abnormal coat appearance | 1 supporting dataset | Fastkd2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 4.2x10-5 | ||
| decreased spleen weight | 1 supporting dataset | Fastkd2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.06x10-5 | ||
| decreased total retina thickness | 1 supporting dataset | Fastkd2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.25x10-5 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Fastkd2tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | Wholemount images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/1) | 7.75% (22/284) |
| cerebellum | heterozygote | Wholemount images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
Human diseases caused by Fastkd2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Fastkd2.
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| Fastkd2tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Fastkd2tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Fastkd2tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |