Med25 | mediator complex subunit 25

GeneMGI:1922863Synonyms: ESTM2, 2610529E18Rik, +1 more

Physiological systems

19 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Adipose tissue Limbs/digits/tail Hearing/vestibular/ear Vision/eye Hematopoietic system Behavior/neurological Skeleton Mortality/aging

11 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased total retina thickness	2 supporting datasets	Med25^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	3.11x10^-8
short tibia	2 supporting datasets	Med25^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	1.08x10^-9
abnormal motor capabilities/coordination/movement	1 supporting dataset	Med25^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	3.05x10^-6
increased total body fat amount	2 supporting datasets	Med25^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	4.59x10^-5
abnormal auditory brainstem response	1 supporting dataset	Med25^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	1.13x10^-5
decreased exploration in new environment	1 supporting dataset	Med25^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	1.19x10^-6
decreased mean corpuscular volume	1 supporting dataset	Med25^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	8.17x10^-6
decreased locomotor activity	2 supporting datasets	Med25^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	1.96x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Med25^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Med25.

Associated images

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Histopathology

There is no histopathology data found for Med25.

IMPC related publications

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External links

No external links available for Med25.

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*Med25^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Med25^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Med25^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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