Med25 | mediator complex subunit 25
Physiological systems
19 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Adipose tissue Limbs/digits/tail Hearing/vestibular/ear Vision/eye Hematopoietic system Behavior/neurological Skeleton Mortality/aging
11 No significant impact
5 Not tested
Data collections
Gene metrics:9Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| decreased total retina thickness | 2 supporting datasets | Med25tm1b(KOMP)Wtsi | heterozygote | Early adult | 3.11x10-8 | ||
| short tibia | 2 supporting datasets | Med25tm1b(KOMP)Wtsi | heterozygote | Early adult | 1.08x10-9 | ||
| abnormal motor capabilities/coordination/movement | 1 supporting dataset | Med25tm1b(KOMP)Wtsi | heterozygote | Early adult | 3.05x10-6 | ||
| increased total body fat amount | 2 supporting datasets | Med25tm1b(KOMP)Wtsi | heterozygote | Early adult | 4.59x10-5 | ||
| abnormal auditory brainstem response | 1 supporting dataset | Med25tm1b(KOMP)Wtsi | heterozygote | Early adult | 1.13x10-5 | ||
| decreased exploration in new environment | 1 supporting dataset | Med25tm1b(KOMP)Wtsi | heterozygote | Early adult | 1.19x10-6 | ||
| decreased mean corpuscular volume | 1 supporting dataset | Med25tm1b(KOMP)Wtsi | heterozygote | Early adult | 8.17x10-6 | ||
| decreased locomotor activity | 2 supporting datasets | Med25tm1b(KOMP)Wtsi | heterozygote | Early adult | 1.96x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Med25tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * |
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Human diseases caused by Med25 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Med25.
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| Med25tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Med25tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Med25tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |