Ing5 | inhibitor of growth family, member 5
Physiological systems
17 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Vision/eye Cardiovascular system Mortality/aging Craniofacial
11 No significant impact
7 Not tested
Data collections
Gene metrics:8Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| sclerocornea | 1 supporting dataset | Ing5em1(IMPC)J | homozygote | Early adult | 6.91x10-5 | ||
| cornea vascularization | 1 supporting dataset | Ing5em1(IMPC)J | homozygote | Early adult | 1.53x10-5 | ||
| increased fasting circulating glucose level | 1 supporting dataset | Ing5em1(IMPC)J | homozygote | Early adult | 1.7x10-6 | ||
| impaired glucose tolerance | 1 supporting dataset | Ing5em1(IMPC)J | homozygote | Early adult | 1.14x10-8 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Ing5em1(IMPC)J | homozygote | Early adult | N/A * | ||
| prolonged QRS complex duration | 1 supporting dataset | Ing5em1(IMPC)J | homozygote | Early adult | 8.89x10-7 | ||
| abnormal snout morphology | 1 supporting dataset | Ing5em1(IMPC)J | homozygote | Early adult | 5.63x10-7 | ||
| increased circulating cholesterol level | 1 supporting dataset | Ing5em1(IMPC)J | homozygote | Early adult | 1.11x10-5 |
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Human diseases caused by Ing5 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ing5.
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| Ing5em1(IMPC)J | Exon Deletion | | mouse |
| Ing5tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Ing5tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Ing5tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |