Ndufs7 | NADH:ubiquinone oxidoreductase core subunit S7
Physiological systems
20 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Integument Embryo Growth/size/body region Limbs/digits/tail Vision/eye Hematopoietic system Mortality/aging
13 No significant impact
4 Not tested
Data collections
Gene metrics:11Significant phenotypes
2Associated diseases
Expression examined in:50Adult tissues
62Embryo tissues
| decreased total retina thickness | 1 supporting dataset | Ndufs7tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 6.23x10-6 | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Ndufs7tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| embryonic growth retardation | 1 supporting dataset | Ndufs7tm1b(EUCOMM)Hmgu | homozygote | E9.5 | N/A * | ||
| embryonic growth retardation | 1 supporting dataset | Ndufs7tm1b(EUCOMM)Hmgu | heterozygote | E9.5 | N/A * | ||
| decreased hemoglobin content | 1 supporting dataset | Ndufs7tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 2.78x10-5 | ||
| abnormal digit morphology | 1 supporting dataset | Ndufs7tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 4.18x10-5 | ||
| abnormal coat/ hair morphology | 1 supporting dataset | Ndufs7tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 8.41x10-6 | ||
| abnormal embryo size | 1 supporting dataset | Ndufs7tm1b(EUCOMM)Hmgu | homozygote | E9.5 | N/A * | ||
| abnormal embryo turning | 1 supporting dataset | Ndufs7tm1b(EUCOMM)Hmgu | heterozygote | E9.5 | N/A * | ||
| abnormal skin coloration | 1 supporting dataset | Ndufs7tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.28x10-7 |
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| adrenal gland | heterozygote | Wholemount images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Wholemount images | 100% (2/2) | 0.19% (1/533) |
| bone | heterozygote | Wholemount images | 100% (2/2) | 0% (0/394) |
| brain | heterozygote | Wholemount images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Wholemount images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Wholemount images | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Wholemount images | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Wholemount images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Wholemount images | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | Wholemount images | 100% (2/2) | 1.67% (7/419) |
Human diseases caused by Ndufs7 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Ndufs7.
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| Ndufs7tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Ndufs7tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Ndufs7tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Ndufs7tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |