Prkd3 | protein kinase D3

GeneMGI:1922542Synonyms: 4930557O20Rik, Prkcn, +2 more

Physiological systems

19 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Vision/eye Mortality/aging Cardiovascular system

15 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased circulating aspartate transaminase level	1 supporting dataset	Prkd3^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	5.39x10^-5
abnormal retina blood vessel morphology	1 supporting dataset	Prkd3^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	5.72x10^-5
decreased circulating cholesterol level	1 supporting dataset	Prkd3^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.42x10^-5
decreased circulating HDL cholesterol level	1 supporting dataset	Prkd3^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.99x10^-5
decreased total retina thickness	2 supporting datasets	Prkd3^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.62x10^-5
preweaning lethality, incomplete penetrance	1 supporting dataset	Prkd3^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Prkd3.

Associated images

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Histopathology

There is no histopathology data found for Prkd3.

IMPC related publications

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External links

No external links available for Prkd3.

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*Prkd3^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Prkd3^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Prkd3^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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