Pik3cb | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
Physiological systems
19 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Pigmentation Integument Hematopoietic system
15 No significant impact
5 Not tested
Data collections
Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| abnormal coat/hair pigmentation | 1 supporting dataset | Pik3cbtm1a(EUCOMM)Wtsi | homozygote | Early adult | 2.17x10-5 | ||
| increased hemoglobin content | 1 supporting dataset | Pik3cbtm1a(EUCOMM)Wtsi | homozygote | Early adult | 5x10-5 | ||
| increased mean corpuscular hemoglobin | 1 supporting dataset | Pik3cbtm1a(EUCOMM)Wtsi | heterozygote | Early adult | 6.31x10-5 | ||
| decreased circulating creatinine level | 1 supporting dataset | Pik3cbtm1a(EUCOMM)Wtsi | heterozygote | Early adult | 3.43x10-6 | ||
| increased hemoglobin content | 1 supporting dataset | Pik3cbtm1a(EUCOMM)Wtsi | heterozygote | Early adult | 1.97x10-5 | ||
| increased mean corpuscular hemoglobin | 1 supporting dataset | Pik3cbtm1a(EUCOMM)Wtsi | homozygote | Early adult | 4.28x10-5 |
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| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/2) | 0% (0/173) |
| bone | heterozygote | n/a | 100% (2/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
Human diseases caused by Pik3cb mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Pik3cb.
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| Pik3cbtm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Pik3cbtm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Pik3cbtm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |