Dhcr24 | 24-dehydrocholesterol reductase
Physiological systems
20 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Behavior/neurological Mortality/aging
17 No significant impact
4 Not tested
Data collections
Gene metrics:3Significant phenotypes
2Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| increased circulating magnesium level | 1 supporting dataset | Dhcr24tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 8.54x10-5 | ||
| abnormal behavior | 2 supporting datasets | Dhcr24tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 4.87x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Dhcr24tm1a(EUCOMM)Wtsi | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/2) | 0% (0/173) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Dhcr24.
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| Dhcr24tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Dhcr24tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |