Setmar | SET domain without mariner transposase fusion
Physiological systems
21 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Pigmentation Integument Vision/eye Hematopoietic system Behavior/neurological Skeleton
14 No significant impact
3 Not tested
Data collections
Gene metrics:14Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| abnormal behavior | 1 supporting dataset | Setmartm1a(EUCOMM)Wtsi | homozygote | Early adult | 6.28x10-7 | ||
| cataract | 1 supporting dataset | Setmartm1a(EUCOMM)Wtsi | homozygote | Early adult | 2.91x10-5 | ||
| abnormal eye morphology | 1 supporting dataset | Setmartm1a(EUCOMM)Wtsi | homozygote | Early adult | 2.42x10-7 | ||
| decreased circulating glycerol level | 2 supporting datasets | Setmartm1a(EUCOMM)Wtsi | homozygote | Early adult | 5.62x10-9 | ||
| abnormal retina morphology | 2 supporting datasets | Setmartm1a(EUCOMM)Wtsi | homozygote | Early adult | 7.35x10-6 | ||
| increased circulating triglyceride level | 1 supporting dataset | Setmartm1a(EUCOMM)Wtsi | homozygote | Early adult | 7.99x10-9 | ||
| increased circulating potassium level | 1 supporting dataset | Setmartm1a(EUCOMM)Wtsi | homozygote | Early adult | 5.94x10-5 | ||
| abnormal gait | 1 supporting dataset | Setmartm1a(EUCOMM)Wtsi | homozygote | Early adult | 8.39x10-5 | ||
| abnormal vertebrae morphology | 1 supporting dataset | Setmartm1a(EUCOMM)Wtsi | homozygote | Early adult | 6.42x10-6 | ||
| thrombocytopenia | 1 supporting dataset | Setmartm1a(EUCOMM)Wtsi | homozygote | Early adult | 1.39x10-5 |
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| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/2) | 0% (0/173) |
| bone | heterozygote | n/a | 0% (0/1) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 50% (1/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
Human diseases caused by Setmar mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Setmar.
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| Setmartm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |