Exoc3l2 | exocyst complex component 3-like 2
Physiological systems
19 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Homeostasis/metabolism Embryo Growth/size/body region Behavior/neurological Skeleton Cardiovascular system Craniofacial Mortality/aging
11 No significant impact
5 Not tested
Gene metrics:11Significant phenotypes
1Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| abnormal cranium morphology | 1 supporting dataset | Exoc3l2tm1a(KOMP)Wtsi | homozygote | Early adult | 1.34x10-7 | ||
| increased circulating serum albumin level | 1 supporting dataset | Exoc3l2em1(IMPC)J | heterozygote | Early adult | 5.14x10-5 | ||
| abnormal embryo size | 1 supporting dataset | Exoc3l2em1(IMPC)J | homozygote | E18.5 | N/A * | ||
| increased circulating iron level | 1 supporting dataset | Exoc3l2tm1b(KOMP)Wtsi | heterozygote | Early adult | 8.17x10-5 | ||
| impaired glucose tolerance | 1 supporting dataset | Exoc3l2em1(IMPC)J | heterozygote | Early adult | 8.64x10-6 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Exoc3l2em1(IMPC)J | homozygote | Early adult | N/A * | ||
| decreased heart weight | 1 supporting dataset | Exoc3l2em1(IMPC)J | heterozygote | Early adult | 6.55x10-6 | ||
| abnormal tooth morphology | 1 supporting dataset | Exoc3l2tm1a(KOMP)Wtsi | homozygote | Early adult | 1.98x10-6 | ||
| decreased grip strength | 2 supporting datasets | Exoc3l2em1(IMPC)J | heterozygote | Early adult | 2.81x10-6 | ||
| abnormal incisor morphology | 1 supporting dataset | Exoc3l2tm1a(KOMP)Wtsi | homozygote | Early adult | 6.43x10-6 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/6) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/6) | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/6) | 0% (0/173) |
| bone | heterozygote | n/a | 0% (0/6) | 0% (0/394) |
| brain | heterozygote | n/a | 0% (0/6) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/6) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/6) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/6) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/6) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/6) | 0.41% (2/491) |
Human diseases caused by Exoc3l2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Exoc3l2.
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| Exoc3l2em1(IMPC)J | Exon Deletion | | mouse |
| Exoc3l2tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Exoc3l2tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Exoc3l2tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |