Ubap2l | ubiquitin-associated protein 2-like
Physiological systems
17 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Embryo Growth/size/body region Limbs/digits/tail Skeleton Cardiovascular system Mortality/aging
11 No significant impact
7 Not tested
Data collections
Gene metrics:6Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| preweaning lethality, complete penetrance | 3 supporting datasets | Ubap2lem1(IMPC)Bay | homozygote | Early adult | N/A * | ||
| short tibia | 1 supporting dataset | Ubap2lem1(IMPC)Bay | heterozygote | Early adult | 7.86x10-5 | ||
| abnormal body wall morphology | 1 supporting dataset | Ubap2lem1(IMPC)Bay | homozygote | E18.5 | N/A * | ||
| prolonged RR interval | 1 supporting dataset | Ubap2lem1(IMPC)Bay | heterozygote | Early adult | 2.53x10-5 | ||
| decreased heart rate | 1 supporting dataset | Ubap2lem1(IMPC)Bay | heterozygote | Early adult | 8.49x10-5 | ||
| abnormal embryo size | 1 supporting dataset | Ubap2lem1(IMPC)Bay | homozygote | E18.5 | N/A * |
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Human diseases caused by Ubap2l mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ubap2l.
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| Ubap2lem1(IMPC)Bay | Exon Deletion | | mouse |
| Ubap2ltm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Ubap2ltm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |