Cyld | CYLD lysine 63 deubiquitinase

GeneMGI:1921506Synonyms: 2010013M14Rik, 2900009M21Rik, +2 more

Physiological systems

16 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Immune system Hematopoietic system Behavior/neurological

13 No significant impact

8 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:5Significant phenotypes
6Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased locomotor activity8 supporting datasetsCyldem2(IMPC)MarchomozygoteEarly adult1.43x10-11 
increased basophil cell number2 supporting datasetsCyldem2(IMPC)MarchomozygoteEarly adult1.96x10-35 
decreased exploration in new environment1 supporting datasetCyldem2(IMPC)MarchomozygoteEarly adult8.32x10-6 
increased grip strength1 supporting datasetCyldem2(IMPC)MarchomozygoteEarly adult5.97x10-9 
increased eosinophil cell number2 supporting datasetsCyldem2(IMPC)MarchomozygoteEarly adult1.35x10-12 
* Does not have a P-value assigned because it was manually marked as significant.
Download data as:  










* This parameter was manually assessed for significance.
Download data as:  

lacZ Expression

Associated images

Loading...

Histopathology

IMPC related publications

Loading...

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

Cyldem2(IMPC)MarcDeletionmouse
Cyldtm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)es cell
Cyldtm1e(EUCOMM)HmguTargeted, non-conditional allelees cell

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter