Cep97 | centrosomal protein 97
Physiological systems
20 / 24 physiological systems tested
10 Significantly impacted by the knock-out
Homeostasis/metabolism Integument Embryo Growth/size/body region Digestive/alimentary Nervous system Vision/eye Cardiovascular system Mortality/aging Craniofacial
10 No significant impact
4 Not tested
Data collections
Gene metrics:8Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
45Embryo tissues
| spina bifida | 1 supporting dataset | Cep97tm1.1(KOMP)Vlcg | heterozygote | E15.5 | N/A * | ||
| cleft palate | 1 supporting dataset | Cep97tm1.1(KOMP)Vlcg | homozygote | E15.5 | N/A * | ||
| preweaning lethality, complete penetrance | 2 supporting datasets | Cep97tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| hemorrhage | 1 supporting dataset | Cep97tm1.1(KOMP)Vlcg | heterozygote | E15.5 | N/A * | ||
| hemorrhage | 1 supporting dataset | Cep97tm1.1(KOMP)Vlcg | homozygote | E15.5 | N/A * | ||
| abnormal craniofacial morphology | 1 supporting dataset | Cep97tm1.1(KOMP)Vlcg | homozygote | E15.5 | N/A * | ||
| spina bifida | 1 supporting dataset | Cep97tm1.1(KOMP)Vlcg | homozygote | E15.5 | N/A * | ||
| edema | 1 supporting dataset | Cep97tm1.1(KOMP)Vlcg | homozygote | E15.5 | N/A * | ||
| bleb | 1 supporting dataset | Cep97tm1.1(KOMP)Vlcg | homozygote | E15.5 | N/A * | ||
| microphthalmia | 1 supporting dataset | Cep97tm1.1(KOMP)Vlcg | homozygote | E15.5 | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/1) | 7.75% (22/284) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
Human diseases caused by Cep97 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Cep97.
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| Cep97tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Cep97tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Cep97tm214236(L1L2_Bact_P) | Reporter-tagged deletion allele (with selection cassette) | | targeting vector |