Arpc5l | actin related protein 2/3 complex, subunit 5-like
Physiological systems
18 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Pigmentation Integument Behavior/neurological
14 No significant impact
6 Not tested
Data collections
Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:49Adult tissues
46Embryo tissues
| abnormal gait | 1 supporting dataset | Arpc5ltm1.1(KOMP)Vlcg | homozygote | Early adult | 5.63x10-7 | ||
| decreased fasting circulating glucose level | 1 supporting dataset | Arpc5ltm1.1(KOMP)Vlcg | heterozygote | Early adult | 5.35x10-5 | ||
| increased circulating alanine transaminase level | 1 supporting dataset | Arpc5ltm1.1(KOMP)Vlcg | heterozygote | Early adult | 2.29x10-6 | ||
| abnormal coat/hair pigmentation | 1 supporting dataset | Arpc5ltm1.1(KOMP)Vlcg | homozygote | Early adult | 2.36x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| bone marrow | heterozygote | Section images | 100% (2/2) | 0% (0/22) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
Human diseases caused by Arpc5l mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Arpc5l.
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| Arpc5ltm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Arpc5ltm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Arpc5ltm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Arpc5ltm33615(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Arpc5ltm33615(L1L2_gt1) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |