Dnm1l | dynamin 1-like
Physiological systems
19 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Integument Nervous system Vision/eye Mortality/aging
15 No significant impact
5 Not tested
Data collections
Gene metrics:6Significant phenotypes
4Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal vitreous body morphology | 1 supporting dataset | Dnm1ltm1b(KOMP)Wtsi | heterozygote | Early adult | 6.81x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Dnm1ltm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| abnormal cornea morphology | 1 supporting dataset | Dnm1ltm1b(KOMP)Wtsi | heterozygote | Early adult | 7.65x10-6 | ||
| abnormal optic disk morphology | 1 supporting dataset | Dnm1ltm1b(KOMP)Wtsi | heterozygote | Early adult | 1.34x10-5 | ||
| persistence of hyaloid vascular system | 1 supporting dataset | Dnm1ltm1b(KOMP)Wtsi | heterozygote | Early adult | 5.47x10-8 | ||
| abnormal coat/ hair morphology | 1 supporting dataset | Dnm1ltm1b(KOMP)Wtsi | heterozygote | Early adult | 8.16x10-5 |
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Human diseases caused by Dnm1l mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Dnm1l.
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| Dnm1ltm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Dnm1ltm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Dnm1ltm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |