Dnm1l | dynamin 1-like

GeneMGI:1921256Synonyms: Drp1, Dnmlp1, +2 more

Physiological systems

19 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Integument Nervous system Vision/eye Mortality/aging

15 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

4Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



abnormal vitreous body morphology	1 supporting dataset	Dnm1l^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	6.81x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Dnm1l^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
abnormal cornea morphology	1 supporting dataset	Dnm1l^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	7.65x10^-6
abnormal optic disk morphology	1 supporting dataset	Dnm1l^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	1.34x10^-5
persistence of hyaloid vascular system	1 supporting dataset	Dnm1l^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	5.47x10^-8
abnormal coat/ hair morphology	1 supporting dataset	Dnm1l^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	8.16x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dnm1l.

Associated images

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Histopathology

There is no histopathology data found for Dnm1l.

IMPC related publications

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External links

No external links available for Dnm1l.

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*Dnm1l^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Dnm1l^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Dnm1l^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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