Atp6v1d | ATPase, H+ transporting, lysosomal V1 subunit D

GeneMGI:1921084Synonyms: Atp6m, Vma8, +3 more

Physiological systems

21 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Growth/size/body region Hematopoietic system Behavior/neurological Cardiovascular system Mortality/aging

16 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

29Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



increased lean body mass	2 supporting datasets	Atp6v1d^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	3.96x10^-5
preweaning lethality, complete penetrance	4 supporting datasets	Atp6v1d^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
cardiovascular system phenotype	1 supporting dataset	Atp6v1d^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	6.65x10^-6
decreased locomotor activity	1 supporting dataset	Atp6v1d^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	6.84x10^-5
decreased mean platelet volume	1 supporting dataset	Atp6v1d^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.87x10^-5
embryonic lethality prior to organogenesis	1 supporting dataset	Atp6v1d^{tm1b(EUCOMM)Hmgu}	homozygote	E9.5	N/A ^*
thrombocytosis	1 supporting dataset	Atp6v1d^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	9.38x10^-6
embryonic lethality prior to tooth bud stage	2 supporting datasets	Atp6v1d^{tm1b(EUCOMM)Hmgu}	homozygote	E12.5	N/A ^*
increased heart rate variability	1 supporting dataset	Atp6v1d^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.63x10^-5
abnormal sinus arrhythmia	1 supporting dataset	Atp6v1d^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	4.85x10^-8

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Atp6v1d.

Associated images

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Histopathology

There is no histopathology data found for Atp6v1d.

IMPC related publications

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External links

No external links available for Atp6v1d.

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*Atp6v1d^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Atp6v1d^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Atp6v1d^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Atp6v1d^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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