Shld1 | shieldin complex subunit 1

GeneMGI:1920997Synonyms: 1110034G24Rik

Physiological systems

20 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Growth/size/body region Liver/biliary system Hematopoietic system Cardiovascular system

13 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Allele:

Phy. System:

Life Stage:



enlarged liver	1 supporting dataset	Shld1^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
increased circulating triglyceride level	1 supporting dataset	Shld1^{em1(IMPC)Wtsi}	homozygote	Early adult	1.07x10^-5
enlarged uterus	1 supporting dataset	Shld1^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
enlarged spleen	2 supporting datasets	Shld1^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
enlarged lymph nodes	1 supporting dataset	Shld1^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
abnormal uterus morphology	1 supporting dataset	Shld1^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
abnormal lymph node morphology	1 supporting dataset	Shld1^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
abnormal spleen morphology	2 supporting datasets	Shld1^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
enlarged heart	1 supporting dataset	Shld1^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
increased red blood cell distribution width	1 supporting dataset	Shld1^{em1(IMPC)Wtsi}	homozygote	Early adult	4.77x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Shld1.

Associated images

30 images

X-ray

XRay Images Whole Body Dorso Ventral

10 images

X-ray

XRay Images Whole Body Lateral Orientation

Histopathology

This gene doesn't have any significant Histopathology hits. Click here to see the raw data

IMPC related publications

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External links

No external links available for Shld1.

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*Shld1^em1(IMPC)Mbp*	Deletion	‌	mouse
*Shld1^{em1(IMPC)Wtsi}*	Exon Deletion	‌	mouse
*Shld1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Shld1^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

My Genes

Shld1 | shieldin complex subunit 1

Physiological systems

7 Significantly impacted by the knock-out

13 No significant impact

4 Not tested

Data collections

Phenotypes

lacZ Expression

Associated images

X-ray

X-ray

Histopathology

IMPC related publications

External links

Order Mouse and ES Cells

The IMPC Newsletter

Access Data Release 22.1 Data