Cst6 | cystatin E/M

GeneMGI:1920970

Physiological systems

24 / 24 physiological systems tested

12 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Integument Growth/size/body region Limbs/digits/tail Vision/eye Hematopoietic system Behavior/neurological Skeleton Mortality/aging Cardiovascular system

12 No significant impact

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:17Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



enlarged spleen	1 supporting dataset	Cst6^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Cst6^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal skin morphology	1 supporting dataset	Cst6^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
hydrometra	1 supporting dataset	Cst6^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
no spontaneous movement	1 supporting dataset	Cst6^{em1(IMPC)Ccpcz}	homozygote	E18.5	N/A ^*
increased circulating creatine kinase level	1 supporting dataset	Cst6^{em1(IMPC)Ccpcz}	heterozygote	Early adult	2.92x10^-12
small spleen	1 supporting dataset	Cst6^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
abnormal rib morphology	1 supporting dataset	Cst6^{em1(IMPC)Ccpcz}	heterozygote	Early adult	2.55x10^-5
abnormal digit morphology	1 supporting dataset	Cst6^{em1(IMPC)Ccpcz}	heterozygote	Early adult	4.99x10^-8
abnormal uterus morphology	1 supporting dataset	Cst6^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* Does not have a P-value assigned because it was manually marked as significant.

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lacZ Expression

No adult expression data available for Cst6.

Associated images

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Histopathology

There is no histopathology data found for Cst6.

IMPC related publications

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External links

No external links available for Cst6.

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*Cst6^{em1(IMPC)Ccpcz}*	Intra-exon deletion	‌	mouse
*Cst6^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Cst6^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Cst6^{tm2e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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